Version 5.4
Mus musculus Protein: Tff3
Summary
InnateDB Protein IDBP-163768.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tff3
Protein Name trefoil factor 3, intestinal
Synonyms ITF; mITF;
Species Mus musculus
Ensembl Protein ENSMUSP00000024827
InnateDB Gene IDBG-163766 (Tff3)
Protein Structure
UniProt Annotation
Function Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). {ECO:0000269PubMed:8824194}.
Subcellular Localization Secreted, extracellular space, extracellular matrix, apical lamina {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in goblet cells of the intestines and colon (at protein level). Expressed abundantly in goblet cells of intestine and colon, and at low levels in stomach. No expression in brain, lung, spleen, kidney, uterus, pancreas, liver, heart or thymus. {ECO:0000269PubMed:7575467, ECO:0000269PubMed:7741746}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0043434 response to peptide hormone
Cellular Component
GO:0030141 secretory granule
GO:0032579 apical lamina of hyaline layer
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:104638
InterPro IPR000519 P-type trefoil
IPR017994 P-type trefoil, chordata
PFAM PF00088
PRINTS PR00680
PIRSF
SMART SM00018
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62395
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 21786
UniGene
RefSeq NP_035705
MGI ID
MGI Symbol Tff3
OMIM
CCDS CCDS37544
HPRD
IMGT
EMBL AJ271004 BC011042 D38410 U24220 U24221 U24222 U46858
GenPept AAB92385 AAC52682 AAH11042 BAA07464 CAB65752

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca