InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gstt1

Summary

InnateDB Protein

IDBP-163791.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gstt1

Protein Name

glutathione S-transferase, theta 1

Synonyms

AI255817; Gstt1-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001713

InnateDB Gene

IDBG-163789 (Gstt1)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity. {ECO:0000269PubMed:20097269}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

In liver, highest expression found in central vein limiting plate hepatocytes. Also expressed in interlobular bile duct epithelial cells. In lung, expressed in Clara cells and ciliated cells of the bronchiolar epithelium and in type II alveolar cells of the lung parenchyma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004602	glutathione peroxidase activity
GO:0005515	protein binding
GO:0047651	alkylhalidase activity

Biological Process

GO:0006304	DNA modification
GO:0006749	glutathione metabolic process
GO:0009751	response to salicylic acid
GO:0010269	response to selenium ion
GO:0014070	response to organic cyclic compound
GO:0018900	dichloromethane metabolic process
GO:0033197	response to vitamin E
GO:0042493	response to drug
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:107379

InterPro

IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM