InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gstt1

Summary

InnateDB Gene

IDBG-163789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gstt1

Gene Name

glutathione S-transferase, theta 1

Synonyms

AI255817; Gstt1-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001663

Encoded Proteins

IDBP-163791

glutathione S-transferase, theta 1

IDBP-401074

glutathione S-transferase, theta 1

IDBP-536517

glutathione S-transferase, theta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:75783813-75798584

Strand

Reverse strand

Band

Transcripts

ENSMUST00000001713	ENSMUSP00000001713
ENSMUST00000120177	ENSMUSP00000113839
ENSMUST00000139724	ENSMUSP00000117130

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004602	glutathione peroxidase activity
GO:0005515	protein binding
GO:0047651	alkylhalidase activity

Biological Process

GO:0006304	DNA modification
GO:0006749	glutathione metabolic process
GO:0009751	response to salicylic acid
GO:0010269	response to selenium ion
GO:0014070	response to organic cyclic compound
GO:0018900	dichloromethane metabolic process
GO:0033197	response to vitamin E
GO:0042493	response to drug
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

null

View Gene Order

ENSBTAG00000040298

Not yet available

Pathways

NETPATH

REACTOME

REACT_243247

Phase II conjugation pathway

REACT_188937

Metabolism pathway

REACT_215316

Glutathione conjugation pathway

REACT_232343

Biological oxidations pathway

KEGG

mmu00480

Glutathione metabolism pathway

mmu00980

Metabolism of xenobiotics by cytochrome P450 pathway

mmu00982

Drug metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_223659

Glutathione conjugation pathway

REACT_218176

Biological oxidations pathway

REACT_219139

Metabolism pathway

REACT_213008

Phase II conjugation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.2746

RefSeq

NM_008185

OMIM

CCDS

CCDS23932

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas