InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dixdc1

Summary

InnateDB Protein

IDBP-163832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dixdc1

Protein Name

DIX domain containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034566

InnateDB Gene

IDBG-163830 (Dixdc1)

Protein Structure

UniProt Annotation

Function

Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269PubMed:15262978, ECO:0000269PubMed:15857680}.

Subcellular Localization

Cell junction, focal adhesion {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Abundantly expressed in brain and testis and to a lower extent in lung, kidney, colon, ovary and urinary bladder. Expressed in brain, liver, testis and spleen (at protein level). Expressed throughout the brain with strong expression in main and accessory olfactory bulbs, cerebral cortex, piriform cortex, hippocampus, habenular nucleus, dorsal thalamus, superior and inferior colliculi and cerebellum. {ECO:0000269PubMed:15857680}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0043015	gamma-tubulin binding

Biological Process

GO:0007049	cell cycle
GO:0007275	multicellular organismal development
GO:0021695	cerebellar cortex development
GO:0021795	cerebral cortex cell migration
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021846	cell proliferation in forebrain
GO:0021869	forebrain ventricular zone progenitor cell division
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030900	forebrain development
GO:0032956	regulation of actin cytoskeleton organization
GO:0043010	camera-type eye development
GO:0045665	negative regulation of neuron differentiation
GO:0046328	regulation of JNK cascade
GO:0046330	positive regulation of JNK cascade
GO:0050772	positive regulation of axonogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0043679	axon terminus