InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dixdc1

Summary

InnateDB Gene

IDBG-163830.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dixdc1

Gene Name

DIX domain containing 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032064

Encoded Proteins

IDBP-163832

DIX domain containing 1

IDBP-401118

DIX domain containing 1

IDBP-401116

DIX domain containing 1

IDBP-401113

DIX domain containing 1

IDBP-401112

DIX domain containing 1

IDBP-401111

DIX domain containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150764:
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway and interacts with AXIN1, DVL2, and MAP3K1. The encoded protein is found associated with gamma tubulin at the centrosome. Three transcript variants, two protein-coding and the other non-protein coding, have been found for this gene. The longer isoform also associates with actin stress fibers while the shorter isoform does not. [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:50662752-50739517

Strand

Reverse strand

Band

A5.3

Transcripts

ENSMUST00000034566	ENSMUSP00000034566
ENSMUST00000121634	ENSMUSP00000113089
ENSMUST00000117646	ENSMUSP00000112431
ENSMUST00000119449
ENSMUST00000120622	ENSMUSP00000113934
ENSMUST00000117093	ENSMUSP00000112654
ENSMUST00000118707	ENSMUSP00000113907
ENSMUST00000141919
ENSMUST00000124424
ENSMUST00000151109
ENSMUST00000149717
ENSMUST00000154315

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0043015	gamma-tubulin binding

Biological Process

GO:0007049	cell cycle
GO:0007275	multicellular organismal development
GO:0021695	cerebellar cortex development
GO:0021795	cerebral cortex cell migration
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021846	cell proliferation in forebrain
GO:0021869	forebrain ventricular zone progenitor cell division
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030900	forebrain development
GO:0032956	regulation of actin cytoskeleton organization
GO:0043010	camera-type eye development
GO:0045665	negative regulation of neuron differentiation
GO:0046328	regulation of JNK cascade
GO:0046330	positive regulation of JNK cascade
GO:0050772	positive regulation of axonogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0043679	axon terminus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000150764

View Gene Order

ENSBTAG00000008665

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_8

Wnt pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.400353 Mm.82598

RefSeq

NM_178118 XM_006510450 XM_006510451 XM_006510452 XM_006510453 XM_006510454

OMIM

CCDS

CCDS23169

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas