Version 5.4
Mus musculus Protein: Efna4
Summary
InnateDB Protein IDBP-163845.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Efna4
Protein Name ephrin A4
Synonyms EFL-4; Epl4; LERK-4;
Species Mus musculus
Ensembl Protein ENSMUSP00000029674
InnateDB Gene IDBG-163843 (Efna4)
Protein Structure
UniProt Annotation
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0007411 axon guidance
GO:0030316 osteoclast differentiation
GO:0046849 bone remodeling
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID MGI:106643
InterPro IPR001799 Ephrin
IPR008972 Cupredoxin
PFAM PF00812
PRINTS PR01347
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08542
PhosphoSite PhosphoSite-O08542
TrEMBL Q3UQB5
UniProt Splice Variant
Entrez Gene 13639
UniGene Mm.16332
RefSeq NP_031936
MGI ID
MGI Symbol Efna4
OMIM
CCDS CCDS38489
HPRD
IMGT
EMBL AK142604 CH466547 U90663 U92889 U92890
GenPept AAB50238 AAC39962 BAE25127 EDL15210

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca