Version 5.4
Mus musculus Gene: Efna4
Summary
InnateDB Gene IDBG-163843.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Efna4
Gene Name ephrin A4
Synonyms EFL-4; Epl4; LERK-4
Species Mus musculus
Ensembl Gene ENSMUSG00000028040
Encoded Proteins
IDBP-163845
ephrin A4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000243364:
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:89333390-89338028
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000029674 ENSMUSP00000029674
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0007411 axon guidance
GO:0030316 osteoclast differentiation
GO:0046849 bone remodeling
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000243364
View Gene Order
ENSBTAG00000010673
Not yet available
Pathways
NETPATH
REACTOME
REACT_243939
EPHA-mediated growth cone collapse pathway
REACT_243590
EPH-ephrin mediated repulsion of cells pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_261444
Axon guidance pathway
REACT_188576
Developmental Biology pathway
KEGG
mmu04360
Axon guidance pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt O08542
TrEMBL Q3UQB5
UniProt Splice Variant
Entrez Gene 13639
UniGene Mm.16332
RefSeq NM_007910
OMIM
CCDS CCDS38489
HPRD
IMGT
MGI ID MGI:106643
MGI Symbol Efna4
EMBL AK142604 CH466547 U90663 U92889 U92890
GenPept AAB50238 AAC39962 BAE25127 EDL15210
RNA Seq Atlas 13639

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca