InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adam15

Summary

InnateDB Protein

IDBP-163902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adam15

Protein Name

a disintegrin and metallopeptidase domain 15 (metargidin)

Synonyms

MDC15; metargidin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029676

InnateDB Gene

IDBG-163900 (Adam15)

Protein Structure

UniProt Annotation

Function

Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration (By similarity). Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Interactions with egg membrane could be mediated via binding between the disintegrin-like domain to one or more integrin receptors on the egg. {ECO:0000250, ECO:0000269PubMed:11882657, ECO:0000269PubMed:12897135, ECO:0000269PubMed:15818704, ECO:0000269PubMed:18390692}.

Subcellular Localization

Endomembrane system {ECO:0000269PubMed:18390692}; Single-pass type I membrane protein {ECO:0000269PubMed:18390692}. Cell junction, adherens junction {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000269PubMed:18390692}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269PubMed:18390692}. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed.

Disease Associations

Tissue Specificity

Expressed moderately in pericytes of retina. Expressed in testis and in spermatozoa from the caput, corpus, and cauda epididymis, as well as in non-capacitated and acrosome- reacted sperm (at protein level). Highly expressed in heart, brain, lung, and kidney. Expressed at lower levels in spleen, liver, testis and muscle. {ECO:0000269PubMed:18381816, ECO:0000269PubMed:18390692}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding

Biological Process

GO:0001525	angiogenesis
GO:0006508	proteolysis
GO:0007155	cell adhesion
GO:0030574	collagen catabolic process
GO:0042246	tissue regeneration
GO:0060317	cardiac epithelial to mesenchymal transition

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005912	adherens junction
GO:0016021	integral component of membrane
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

MGI:1333882

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt