Version 5.4
Mus musculus Gene: Adam15
Summary
InnateDB Gene IDBG-163900.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adam15
Gene Name a disintegrin and metallopeptidase domain 15 (metargidin)
Synonyms MDC15; metargidin
Species Mus musculus
Ensembl Gene ENSMUSG00000028041
Encoded Proteins
IDBP-163902
a disintegrin and metallopeptidase domain 15 (metargidin)
IDBP-163904
a disintegrin and metallopeptidase domain 15 (metargidin)
IDBP-266638
a disintegrin and metallopeptidase domain 15 (metargidin)
IDBP-266642
a disintegrin and metallopeptidase domain 15 (metargidin)
IDBP-790207
a disintegrin and metallopeptidase domain 15 (metargidin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143537:
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:89338542-89349996
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000029676 ENSMUSP00000029676
ENSMUST00000074582 ENSMUSP00000074167
ENSMUST00000107448 ENSMUSP00000103072
ENSMUST00000107446 ENSMUSP00000103070
ENSMUST00000148068
ENSMUST00000156250
ENSMUST00000139705
ENSMUST00000155868
ENSMUST00000144608
ENSMUST00000134839
ENSMUST00000155295
ENSMUST00000134590
ENSMUST00000184651 ENSMUSP00000139147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
Biological Process
GO:0001525 angiogenesis
GO:0006508 proteolysis
GO:0007155 cell adhesion
GO:0030574 collagen catabolic process
GO:0042246 tissue regeneration
GO:0060317 cardiac epithelial to mesenchymal transition
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005912 adherens junction
GO:0016021 integral component of membrane
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143537
View Gene Order
ENSBTAG00000010663
Not yet available
Pathways
NETPATH
REACTOME
REACT_206066
Extracellular matrix organization pathway
REACT_199052
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.274049 Mm.416037 Mm.434209
RefSeq NM_001037722 NM_009614 XM_006500918
OMIM
CCDS CCDS17502 CCDS17503
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca