InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sepsecs

Summary

InnateDB Protein

IDBP-163916.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sepsecs

Protein Name

Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031069

InnateDB Gene

IDBG-163914 (Sepsecs)

Protein Structure

UniProt Annotation

Function

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0016785	transferase activity, transferring selenium-containing groups
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0001514	selenocysteine incorporation
GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1098791

InterPro

IPR008829 Soluble liver antigen/liver pancreas antigen
IPR015424 Pyridoxal phosphate-dependent transferase
IPR019872 O-phosphoseryl-tRNA(Sec) selenium transferase

PFAM

PF05889

PRINTS

PIRSF

PIRSF017689

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6P6M7