Version 5.4
Mus musculus Gene: Sepsecs
Summary
InnateDB Gene IDBG-163914.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sepsecs
Gene Name Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000029173
Encoded Proteins
IDBP-163916
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
IDBP-540706
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
IDBP-534900
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
IDBP-538317
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109618:
The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:52640087-52669729
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000031069 ENSMUSP00000031069
ENSMUST00000150709 ENSMUSP00000115477
ENSMUST00000126574 ENSMUSP00000114413
ENSMUST00000123856 ENSMUSP00000114760
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016785 transferase activity, transferring selenium-containing groups
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0001514 selenocysteine incorporation
GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109618
View Gene Order
ENSBTAG00000014616
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00970
Aminoacyl-tRNA biosynthesis pathway
mmu00450
Selenocompound metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00450
Selenocompound metabolism pathway
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.244719 Mm.405806 Mm.475590
RefSeq NM_172490
OMIM
CCDS CCDS19286
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca