InnateDB Protein
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IDBP-163978.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pi4k2b
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Protein Name
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phosphatidylinositol 4-kinase type 2 beta
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Synonyms
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2610042N09Rik; 4933409G22Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000031082
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InnateDB Gene
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IDBG-163974 (Pi4k2b)
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Protein Structure
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Function |
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914323
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InterPro |
IPR000403
Phosphatidylinositol 3-/4-kinase, catalytic domain
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PFAM |
PF00454
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PRINTS |
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PIRSF |
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SMART |
SM00146
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CBQ5
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PhosphoSite |
PhosphoSite-Q8CBQ5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
67073
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UniGene |
Mm.468296
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RefSeq |
NP_083020
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MGI ID |
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MGI Symbol |
Pi4k2b
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OMIM |
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CCDS |
CCDS39086
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HPRD |
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IMGT |
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EMBL |
AF411321
AK011751
AK016754
AK035523
AK170730
AY148879
BC010257
BC062144
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GenPept |
AAH10257
AAH62144
AAL04155
AAN37399
BAB27819
BAB30411
BAC29091
BAE41986
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