InnateDB Protein
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IDBP-164043.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Smarcb1
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Protein Name
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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
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Synonyms
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AU020204; Baf47; Ini1; Snf5; SNF5/INI1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000000925
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InnateDB Gene
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IDBG-164041 (Smarcb1)
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Protein Structure
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Function |
Core component of the BAF (SWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000250, ECO:0000269PubMed:17640523}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 127 interaction(s) predicted by orthology.
Experimentally validated |
Total |
30
[view]
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Protein-Protein |
29
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
127 [view]
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Molecular Function |
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Biological Process |
GO:0001824
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blastocyst development
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GO:0001835
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blastocyst hatching
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GO:0006281
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DNA repair
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GO:0006337
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nucleosome disassembly
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GO:0006338
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chromatin remodeling
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GO:0006351
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transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0007399
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nervous system development
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GO:0008285
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negative regulation of cell proliferation
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GO:0030154
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cell differentiation
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GO:0039692
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single stranded viral RNA replication via double stranded DNA intermediate
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GO:0043044
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ATP-dependent chromatin remodeling
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GO:0043923
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positive regulation by host of viral transcription
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GO:0044772
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mitotic cell cycle phase transition
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0051091
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positive regulation of sequence-specific DNA binding transcription factor activity
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Cellular Component |
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PDB ID |
MGI:1328366
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InterPro |
IPR006939
SNF5/SMARCB1/INI1
IPR017393
SWI/SNF chromatin-remodeling complex, component hSNF5/Ini1
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PFAM |
PF04855
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PRINTS |
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PIRSF |
PIRSF038126
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z0H3
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PhosphoSite |
PhosphoSite-Q9Z0H3
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TrEMBL |
Q6ZWP4
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UniProt Splice Variant |
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Entrez Gene |
20587
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UniGene |
Mm.279751
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RefSeq |
NP_035548
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MGI ID |
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MGI Symbol |
Smarcb1
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OMIM |
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CCDS |
CCDS23936
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HPRD |
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IMGT |
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EMBL |
AJ011739
AJ011740
AK075906
BC025163
CH466553
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GenPept |
AAH25163
BAC36045
CAA09760
CAA09761
EDL31872
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