InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde9a

Summary

InnateDB Protein

IDBP-164230.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde9a

Protein Name

phosphodiesterase 9A

Synonyms

PDE9A1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038005

InnateDB Gene

IDBG-164228 (Pde9a)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in kidney. Lower levels in liver, lung and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0019934	cGMP-mediated signaling

Cellular Component

GO:0005829	cytosol
GO:0043204	perikaryon

Protein Structure and Domains

PDB ID

MGI:1277179

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt