Version 5.4
Mus musculus Gene: Pde9a
Summary
InnateDB Gene IDBG-164228.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pde9a
Gene Name phosphodiesterase 9A
Synonyms PDE9A1
Species Mus musculus
Ensembl Gene ENSMUSG00000041119
Encoded Proteins
IDBP-164230
phosphodiesterase 9A
IDBP-540505
phosphodiesterase 9A
IDBP-532448
phosphodiesterase 9A
IDBP-532207
phosphodiesterase 9A
IDBP-535807
phosphodiesterase 9A
IDBP-538938
phosphodiesterase 9A
IDBP-541989
phosphodiesterase 9A
IDBP-533531
phosphodiesterase 9A
IDBP-541150
phosphodiesterase 9A
IDBP-532651
phosphodiesterase 9A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160191:
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:31386234-31476310
Strand Forward strand
Band B1
Transcripts
ENSMUST00000047168 ENSMUSP00000038005
ENSMUST00000143549 ENSMUSP00000117911
ENSMUST00000131417 ENSMUSP00000115188
ENSMUST00000134525 ENSMUSP00000121003
ENSMUST00000127929 ENSMUSP00000117611
ENSMUST00000137927 ENSMUSP00000121126
ENSMUST00000124902 ENSMUSP00000118869
ENSMUST00000154567
ENSMUST00000141314 ENSMUSP00000117364
ENSMUST00000136384 ENSMUSP00000116724
ENSMUST00000130547
ENSMUST00000155395
ENSMUST00000154392 ENSMUSP00000117065
ENSMUST00000155113
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0007165 signal transduction
GO:0008152 metabolic process
GO:0019934 cGMP-mediated signaling
Cellular Component
GO:0005829 cytosol
GO:0043204 perikaryon
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160191
View Gene Order
ENSBTAG00000021899
Not yet available
Pathways
NETPATH
REACTOME
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_229620
cGMP effects pathway
REACT_245499
Nitric oxide stimulates guanylate cyclase pathway
KEGG
mmu00230
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23767
cGMP effects pathway
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_604
Hemostasis pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt O70628
TrEMBL D3Z408
UniProt Splice Variant
Entrez Gene 18585
UniGene Mm.10812
RefSeq NM_001163748 NM_008804 XM_006523821 XM_006523822
OMIM
CCDS CCDS28605
HPRD
IMGT
MGI ID MGI:1277179
MGI Symbol Pde9a
EMBL AC154652 AC166172 AF031147 AF068247 BC061163
GenPept AAC23996 AAC24344 AAH61163
RNA Seq Atlas 18585

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca