InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zbtb7b

Summary

InnateDB Protein

IDBP-164324.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zbtb7b

Protein Name

zinc finger and BTB domain containing 7B

Synonyms

c-Krox; Thpok; Zfp67;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029677

InnateDB Gene

IDBG-164322 (Zbtb7b)

Protein Structure

UniProt Annotation

Function

Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes. {ECO:0000269PubMed:15729333, ECO:0000269PubMed:7937772}.

Subcellular Localization

Nucleus.

Disease Associations

Note=Defects in Zbtb7b are the cause of helper deficient disease (HD). HD mice are distinguished by the virtual absence of peripheral T-cells of the CD4(+)CD8(-) major histocompatibility complex (MHC) class II-restricted T-helper subset due to a specific block in thymic development. The developmental defect is selective for CD4(+)CD8(-) cells; the maturation of CD4(-)CD8(+) and gamma delta T-cells is normal indicating that lineage commitment is specifically perturbed without affecting positive selection.

Tissue Specificity

Widely expressed, with a higher level in skin. Expressed in thymus. Restricted to CD4 cells (mature single positive CD4(+) and intermediate CD4(+)CD8(+) cells). {ECO:0000269PubMed:15729333, ECO:0000269PubMed:7937772}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0010628	positive regulation of gene expression
GO:0030154	cell differentiation
GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter