Version 5.4
Mus musculus Gene: Zbtb7b
Summary
InnateDB Gene IDBG-164322.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zbtb7b
Gene Name zinc finger and BTB domain containing 7B
Synonyms c-Krox; Thpok; Zfp67
Species Mus musculus
Ensembl Gene ENSMUSG00000028042
Encoded Proteins
IDBP-164324
zinc finger and BTB domain containing 7B
IDBP-266689
zinc finger and BTB domain containing 7B
IDBP-266691
zinc finger and BTB domain containing 7B
IDBP-266693
zinc finger and BTB domain containing 7B
IDBP-540064
zinc finger and BTB domain containing 7B
IDBP-537599
zinc finger and BTB domain containing 7B
IDBP-536072
zinc finger and BTB domain containing 7B
IDBP-535224
zinc finger and BTB domain containing 7B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160685:
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:89377644-89394776
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000029677 ENSMUSP00000029677
ENSMUST00000107435 ENSMUSP00000103058
ENSMUST00000107433 ENSMUSP00000103056
ENSMUST00000107432 ENSMUSP00000103055
ENSMUST00000126027 ENSMUSP00000123348
ENSMUST00000142119 ENSMUSP00000115425
ENSMUST00000148361 ENSMUSP00000121498
ENSMUST00000124783 ENSMUSP00000120641
ENSMUST00000139094
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0010628 positive regulation of gene expression
GO:0030154 cell differentiation
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160685
View Gene Order
ENSBTAG00000021512
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.262184 Mm.488956
RefSeq NM_009565 XM_006501313 XM_006501314 XM_006501315 XM_006501316 XM_006501317 XM_006501318 XM_006501319
OMIM
CCDS CCDS17504
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca