InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Add2

Summary

InnateDB Protein

IDBP-164368.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Add2

Protein Name

adducin 2 (beta)

Synonyms

2900072M03Rik; add97;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032069

InnateDB Gene

IDBG-164366 (Add2)

Protein Structure

UniProt Annotation

Function

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005516	calmodulin binding
GO:0030507	spectrin binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0006461	protein complex assembly
GO:0030097	hemopoiesis
GO:0032092	positive regulation of protein binding
GO:0051016	barbed-end actin filament capping
GO:0051017	actin filament bundle assembly