Version 5.4
Mus musculus Gene: Add2
Summary
InnateDB Gene IDBG-164366.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Add2
Gene Name adducin 2 (beta)
Synonyms 2900072M03Rik; add97
Species Mus musculus
Ensembl Gene ENSMUSG00000030000
Encoded Proteins
IDBP-164368
adducin 2 (beta)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the beta subunit of the adducin family. Adducins, encoded by alpha, beta and gamma genes, are heteromeric proteins that crosslink actin filaments with spectrin at the cytoskeletal membrane. This protein, primarily found in the brain and hematopoietic cells, is regulated by phosphorylation and calmodulin interactions as it promotes spectrin assembly onto actin filaments, bundles actin and caps barbed ends of actin filaments. In mouse, deficiency of this gene can lead to mild hemolytic anemia and impaired synaptic plasticity. Mutations of this gene in mouse serve as a pathophysiological model for hereditary spherocytosis and hereditary elliptocytosis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:86078084-86119555
Strand Forward strand
Band C3
Transcripts
ENSMUST00000032069 ENSMUSP00000032069
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005516 calmodulin binding
GO:0030507 spectrin binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051015 actin filament binding
Biological Process
GO:0006461 protein complex assembly
GO:0030097 hemopoiesis
GO:0032092 positive regulation of protein binding
GO:0051016 barbed-end actin filament capping
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0005886 plasma membrane
GO:0008290 F-actin capping protein complex
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000075340
View Gene Order
ENSBTAG00000009076
Not yet available
Cross-References
SwissProt Q9QYB8
TrEMBL
UniProt Splice Variant
Entrez Gene 11519
UniGene Mm.104155
RefSeq NM_001271857 NM_001271858 NM_001271859 NM_013458
OMIM
CCDS CCDS20308
HPRD
IMGT
MGI ID MGI:87919
MGI Symbol Add2
EMBL AF100422 AF100423 AF189769 AF189770 AK014496 AK028425 AK156954 BC046783 BC053032
GenPept AAF24972 AAF24973 AAF29502 AAF29503 AAH46783 AAH53032 BAB29395 BAC25943 BAE33913
RNA Seq Atlas 11519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca