Version 5.4
Homo sapiens Protein: DPPA3
Summary
InnateDB Protein IDBP-16438.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPPA3
Protein Name developmental pluripotency associated 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000339250
InnateDB Gene IDBG-16436 (DPPA3)
Protein Structure
UniProt Annotation
Function Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:21421998}. Cytoplasm {ECO:0000269PubMed:21421998}. Note=Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker. {ECO:0000250}.
Disease Associations
Tissue Specificity Low expression in testis, ovary and thymus. Expressed in embryonic stem and carcinoma cells. Highly expressed in testicular germ cell tumors. {ECO:0000269PubMed:14654002, ECO:0000269PubMed:14684992, ECO:0000269PubMed:14990856}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035064 methylated histone binding
Biological Process
GO:0016568 chromatin modification
GO:0040016 embryonic cleavage
GO:0044726 protection of DNA demethylation of female pronucleus
GO:1901536 negative regulation of DNA demethylation
GO:2000653 regulation of genetic imprinting
Cellular Component
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6W0C5
PhosphoSite PhosphoSite-Q6W0C5
TrEMBL
UniProt Splice Variant
Entrez Gene 359787
UniGene Hs.131358
RefSeq NP_954980
HUGO HGNC:19199
OMIM 608408
CCDS CCDS8582
HPRD 16331
IMGT
EMBL AY230136 AY317075 BC062480 BC125145
GenPept AAH62480 AAI25146 AAO39708 AAQ84110

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca