InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hnrnpl

Summary

InnateDB Protein

IDBP-164525.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnpl

Protein Name

heterogeneous nuclear ribonucleoprotein L

Synonyms

C79783; D830027H13Rik; Hnrpl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049407

InnateDB Gene

IDBG-164523 (Hnrnpl)

Protein Structure

UniProt Annotation

Function

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0044212	transcription regulatory region DNA binding