Version 5.4
Mus musculus Gene: Hnrnpl
Summary
InnateDB Gene IDBG-164523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnrnpl
Gene Name heterogeneous nuclear ribonucleoprotein L
Synonyms C79783; D830027H13Rik; Hnrpl
Species Mus musculus
Ensembl Gene ENSMUSG00000015165
Encoded Proteins
IDBP-164525
heterogeneous nuclear ribonucleoprotein L
IDBP-623781
heterogeneous nuclear ribonucleoprotein L
IDBP-623782
heterogeneous nuclear ribonucleoprotein L
IDBP-623783
heterogeneous nuclear ribonucleoprotein L
IDBP-623784
heterogeneous nuclear ribonucleoprotein L
IDBP-623789
heterogeneous nuclear ribonucleoprotein L
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24371310
[Homo sapiens] THRIL, a large intergenic noncoding RNA, binds to heterogenous nuclear ribonucleoprotein L (HNRNPL) and forms a functional THRIL-HNRNPL complex that regulates transcription of TNF by binding to its promoter.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104824:
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:28808541-28822266
Strand Forward strand
Band B1
Transcripts
ENSMUST00000038572 ENSMUSP00000049407
ENSMUST00000174548 ENSMUSP00000133728
ENSMUST00000173750
ENSMUST00000172529 ENSMUSP00000133932
ENSMUST00000172884 ENSMUSP00000134271
ENSMUST00000174477 ENSMUSP00000134734
ENSMUST00000174755
ENSMUST00000174882 ENSMUSP00000133952
ENSMUST00000174396
ENSMUST00000173818
ENSMUST00000172841
ENSMUST00000173578
ENSMUST00000174526
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 69 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0045120 pronucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000104824
View Gene Order
Pathways
NETPATH
REACTOME
REACT_249110
mRNA Splicing pathway
REACT_233572
Gene Expression pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.9043
RefSeq NM_177301 XM_006539556 XM_006539557 XM_006539558 XM_006539559 XM_006539560
OMIM
CCDS CCDS39864
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca