InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbpj

Summary

InnateDB Protein

IDBP-164660.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbpj

Protein Name

recombination signal binding protein for immunoglobulin kappa J region

Synonyms

AI843960; CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa; RBPjk; Rbpsuh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040694

InnateDB Gene

IDBG-164658 (Rbpj)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. {ECO:0000269PubMed:7566092}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}. Note=Mainly nuclear, upon interaction with RITA1, translocates to the cytoplasm, down-regulating the Notch signaling pathway. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	13 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001756	somitogenesis
GO:0001837	epithelial to mesenchymal transition
GO:0001947	heart looping
GO:0001974	blood vessel remodeling
GO:0002437	inflammatory response to antigenic stimulus
GO:0003139	secondary heart field specification
GO:0003151	outflow tract morphogenesis
GO:0003157	endocardium development
GO:0003160	endocardium morphogenesis
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003214	cardiac left ventricle morphogenesis
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0003256	regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006959	humoral immune response
GO:0007219	Notch signaling pathway
GO:0007221	positive regulation of transcription of Notch receptor target
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009912	auditory receptor cell fate commitment
GO:0009957	epidermal cell fate specification
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0021983	pituitary gland development
GO:0030097	hemopoiesis
GO:0030182	neuron differentiation
GO:0030183	B cell differentiation
GO:0030216	keratinocyte differentiation
GO:0030279	negative regulation of ossification
GO:0030513	positive regulation of BMP signaling pathway
GO:0035019	somatic stem cell maintenance
GO:0035481	positive regulation of Notch signaling pathway involved in heart induction
GO:0035912	dorsal aorta morphogenesis
GO:0036302	atrioventricular canal development
GO:0042742	defense response to bacterium
GO:0045165	cell fate commitment
GO:0045596	negative regulation of cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048505	regulation of timing of cell differentiation
GO:0048733	sebaceous gland development
GO:0048820	hair follicle maturation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060486	Clara cell differentiation
GO:0060716	labyrinthine layer blood vessel development
GO:0060844	arterial endothelial cell fate commitment
GO:0060853	Notch signaling pathway involved in arterial endothelial cell fate commitment
GO:0061344	regulation of cell adhesion involved in heart morphogenesis
GO:0061371	determination of heart left/right asymmetry
GO:0072554	blood vessel lumenization
GO:0072602	interleukin-4 secretion
GO:0097101	blood vessel endothelial cell fate specification
GO:1901186	positive regulation of ERBB signaling pathway
GO:1901189	positive regulation of ephrin receptor signaling pathway
GO:1901297	positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis

Cellular Component

GO:0002193	MAML1-RBP-Jkappa- ICN1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:96522

InterPro

IPR002909 IPT domain
IPR008967 p53-like transcription factor, DNA-binding
IPR014756 Immunoglobulin E-set
IPR015350 Beta-trefoil DNA-binding domain
IPR015351 LAG1, DNA binding

PFAM

PF01833
PF09270
PF09271

PRINTS

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P31266