Version 5.4
Mus musculus Gene: Rbpj
Summary
InnateDB Gene IDBG-164658.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rbpj
Gene Name recombination signal binding protein for immunoglobulin kappa J region
Synonyms AI843960; CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa; RBPjk; Rbpsuh
Species Mus musculus
Ensembl Gene ENSMUSG00000039191
Encoded Proteins
IDBP-164648
recombination signal binding protein for immunoglobulin kappa J region
IDBP-164660
recombination signal binding protein for immunoglobulin kappa J region
IDBP-252974
recombination signal binding protein for immunoglobulin kappa J region
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168214:
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2011]
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:53555779-53657445
Strand Forward strand
Band C1
Transcripts
ENSMUST00000087360 ENSMUSP00000084618
ENSMUST00000037618 ENSMUSP00000040694
ENSMUST00000113865 ENSMUSP00000109496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 13 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001756 somitogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001947 heart looping
GO:0001974 blood vessel remodeling
GO:0002437 inflammatory response to antigenic stimulus
GO:0003139 secondary heart field specification
GO:0003151 outflow tract morphogenesis
GO:0003157 endocardium development
GO:0003160 endocardium morphogenesis
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003214 cardiac left ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006959 humoral immune response
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009912 auditory receptor cell fate commitment
GO:0009957 epidermal cell fate specification
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0021983 pituitary gland development
GO:0030097 hemopoiesis
GO:0030182 neuron differentiation
GO:0030183 B cell differentiation
GO:0030216 keratinocyte differentiation
GO:0030279 negative regulation of ossification
GO:0030513 positive regulation of BMP signaling pathway
GO:0035019 somatic stem cell maintenance
GO:0035481 positive regulation of Notch signaling pathway involved in heart induction
GO:0035912 dorsal aorta morphogenesis
GO:0036302 atrioventricular canal development
GO:0042742 defense response to bacterium
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048505 regulation of timing of cell differentiation
GO:0048733 sebaceous gland development
GO:0048820 hair follicle maturation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060486 Clara cell differentiation
GO:0060716 labyrinthine layer blood vessel development
GO:0060844 arterial endothelial cell fate commitment
GO:0060853 Notch signaling pathway involved in arterial endothelial cell fate commitment
GO:0061344 regulation of cell adhesion involved in heart morphogenesis
GO:0061371 determination of heart left/right asymmetry
GO:0072554 blood vessel lumenization
GO:0072602 interleukin-4 secretion
GO:0097101 blood vessel endothelial cell fate specification
GO:1901186 positive regulation of ERBB signaling pathway
GO:1901189 positive regulation of ephrin receptor signaling pathway
GO:1901297 positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis
Cellular Component
GO:0002193 MAML1-RBP-Jkappa- ICN1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000168214
View Gene Order
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_196593
NOTCH2 intracellular domain regulates transcription pathway
REACT_196589
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_223683
Notch-HLH transcription pathway pathway
REACT_222486
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199412
Signaling by NOTCH2 pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_196494
Pre-NOTCH Expression and Processing pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_268602
Pre-NOTCH Transcription and Translation pathway
REACT_233572
Gene Expression pathway
REACT_188576
Developmental Biology pathway
REACT_196464
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_205507
Regulation of beta-cell development pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_231152
Signaling by NOTCH pathway
REACT_196591
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
KEGG
mmu04330
Notch signaling pathway pathway
INOH
INOH website
Notch signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_14835
Notch-HLH transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_13673
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway
REACT_111045
Developmental Biology pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_13698
Regulation of beta-cell development pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_118721
Signaling by NOTCH2 pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_163910
NOTCH2 intracellular domain regulates transcription pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa04330
Notch signaling pathway pathway
INOH
INOH website
Notch signaling pathway pathway
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
hes_heypathway
Notch-mediated HES/HEY network
notch_pathway
Notch signaling pathway
Cross-References
SwissProt P31266
TrEMBL A0N920 E9Q7W0 Q3U6F1 Q3UM17
UniProt Splice Variant
Entrez Gene 19664
UniGene Mm.209292 Mm.409820 Mm.451030 Mm.468225
RefSeq NM_001080927 NM_001080928 NM_001277116 NM_009035 XM_006503795 XM_006503796 XM_006503797 XM_006503798 XM_006503799
OMIM
CCDS CCDS19292 CCDS51503 CCDS51504
HPRD
IMGT
MGI ID MGI:96522
MGI Symbol Rbpj
EMBL AC084054 AK080359 AK145187 AK153163 BC051387 M81865 M81866 M81867 M81868 M81869 M81870 M81872 M81873 M81874 M81875 M81876 M81877 S63463 X17459 X58337
GenPept AAA39018 AAA39019 AAA39020 AAA39021 AAA39022 AAA39023 AAB20195 AAH51387 BAC37889 BAE26281 BAE31773 CAA35501 CAB38078
RNA Seq Atlas 19664

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca