InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rec8

Summary

InnateDB Protein

IDBP-164694.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rec8

Protein Name

REC8 homolog (yeast)

Synonyms

mrec; Rec8L1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002395

InnateDB Gene

IDBG-164692 (Rec8)

Protein Structure

UniProt Annotation

Function

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. {ECO:0000269PubMed:12034751, ECO:0000269PubMed:15515002, ECO:0000269PubMed:15935783, ECO:0000269PubMed:16855401}.

Subcellular Localization

Nucleus. Chromosome. Chromosome, centromere. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II.

Disease Associations

Tissue Specificity

Expressed primarily in the gonads. In the testis, expressed in pachytene spermatocytes and in spermatids. Not expressed in spermatogonia or somatic cells. In the ovary, expressed only in oocytes. Low levels also detected in a number of somatic tissues including thymus, lung, liver, kidney and small intestine. {ECO:0000269PubMed:10207075, ECO:0000269PubMed:12130806, ECO:0000269PubMed:12759374, ECO:0000269PubMed:15935783}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0001556	oocyte maturation
GO:0007059	chromosome segregation
GO:0007126	meiotic nuclear division
GO:0007129	synapsis
GO:0007141	male meiosis I
GO:0007286	spermatid development
GO:0009566	fertilization
GO:0030999	linear element assembly
GO:0072520	seminiferous tubule development

Cellular Component

GO:0000228	nuclear chromosome
GO:0000778	condensed nuclear chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0000794	condensed nuclear chromosome
GO:0000795	synaptonemal complex
GO:0000800	lateral element
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0030893	meiotic cohesin complex
GO:0034991	nuclear meiotic cohesin complex