InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rec8

Summary

InnateDB Gene

IDBG-164692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rec8

Gene Name

REC8 homolog (yeast)

Synonyms

mrec; Rec8L1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002324

Encoded Proteins

IDBP-164694

REC8 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100918:
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:55618037-55625395

Strand

Forward strand

Band

Transcripts

ENSMUST00000002395	ENSMUSP00000002395
ENSMUST00000140335
ENSMUST00000141425
ENSMUST00000155193

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0001556	oocyte maturation
GO:0007059	chromosome segregation
GO:0007126	meiotic nuclear division
GO:0007129	synapsis
GO:0007141	male meiosis I
GO:0007286	spermatid development
GO:0009566	fertilization
GO:0030999	linear element assembly
GO:0072520	seminiferous tubule development

Cellular Component

GO:0000228	nuclear chromosome
GO:0000778	condensed nuclear chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0000794	condensed nuclear chromosome
GO:0000795	synaptonemal complex
GO:0000800	lateral element
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0030893	meiotic cohesin complex
GO:0034991	nuclear meiotic cohesin complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000100918

View Gene Order

ENSBTAG00000002705

Not yet available

Pathways

NETPATH

REACTOME

REACT_75800

Meiotic Synapsis pathway

REACT_200794

Mus musculus biological processes pathway

REACT_198626

Meiotic synapsis pathway

REACT_188804

Cell Cycle pathway

REACT_198624

Meiosis pathway

KEGG

mmu04114

Oocyte meiosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75792

Meiotic synapsis pathway

REACT_115566

Cell Cycle pathway

REACT_111183

Meiosis pathway

KEGG

hsa04114

Oocyte meiosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.23149 Mm.488691

RefSeq

NM_020002 XM_006519319

OMIM

CCDS

CCDS27120

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas