Version 5.4
Homo sapiens Protein: CLEC4C
Summary
InnateDB Protein IDBP-16476.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC4C
Protein Name C-type lectin domain family 4, member C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000346648
InnateDB Gene IDBG-16472 (CLEC4C)
Protein Structure
UniProt Annotation
Function Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. {ECO:0000269PubMed:11031109, ECO:0000269PubMed:11748283}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha. {ECO:0000269PubMed:11031109, ECO:0000269PubMed:11536172, ECO:0000269PubMed:11748283}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WTT0
PhosphoSite PhosphoSite-
TrEMBL H0YFH6
UniProt Splice Variant
Entrez Gene 170482
UniGene Hs.351812
RefSeq
HUGO HGNC:13258
OMIM 606677
CCDS CCDS8584
HPRD 09453
IMGT
EMBL AC006517 AF293615 AF325459 AF325460 AY358223 BC074967 BC074968 BC102015 BC102016 BC102017 BC114338 CH471116
GenPept AAH74967 AAH74968 AAI02016 AAI02017 AAI02018 AAI14339 AAL37036 AAL37358 AAL37359 AAQ88590 EAW88655 EAW88656

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca