InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atic

Summary

InnateDB Protein

IDBP-164932.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atic

Protein Name

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

Synonyms

2610509C24Rik; AA536954; AW212393;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027384

InnateDB Gene

IDBG-164930 (Atic)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003937	IMP cyclohydrolase activity
GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0003360	brainstem development
GO:0006164	purine nucleotide biosynthetic process
GO:0006189	'de novo' IMP biosynthetic process
GO:0009116	nucleoside metabolic process
GO:0009259	ribonucleotide metabolic process
GO:0010035	response to inorganic substance
GO:0021549	cerebellum development
GO:0021987	cerebral cortex development
GO:0031100	organ regeneration
GO:0046452	dihydrofolate metabolic process
GO:0046654	tetrahydrofolate biosynthetic process