Version 5.4
Mus musculus Protein: Tctn3
Summary
InnateDB Protein IDBP-165000.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tctn3
Protein Name tectonic family member 3
Synonyms 4930521E07Rik; AI197391; Tect3;
Species Mus musculus
Ensembl Protein ENSMUSP00000025981
InnateDB Gene IDBG-164998 (Tctn3)
Protein Structure
UniProt Annotation
Function Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway. {ECO:0000250, ECO:0000269PubMed:21725307}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007224 smoothened signaling pathway
GO:0060271 cilium morphogenesis
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1914840
InterPro IPR011677 Domain of unknown function DUF1619
PFAM PF07773
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R2Q6
PhosphoSite PhosphoSite-Q8R2Q6
TrEMBL
UniProt Splice Variant
Entrez Gene 67590
UniGene
RefSeq NP_080536
MGI ID
MGI Symbol Tctn3
OMIM
CCDS CCDS29804
HPRD
IMGT
EMBL AK015861 AK016982 AK030156 BC027335 BC080805 DQ278871
GenPept AAH27335 AAH80805 ABB90563 BAB30004 BAB30537 BAC26813

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca