InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ift57

Summary

InnateDB Protein

IDBP-165058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ift57

Protein Name

intraflagellar transport 57 homolog (Chlamydomonas)

Synonyms

4833420A15Rik; Esrrbl1; Hippi; MHS4R2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046645

InnateDB Gene

IDBG-165056 (Ift57)

Protein Structure

UniProt Annotation

Function

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. {ECO:0000269PubMed:17027958}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Note=Concentrates within the inner segment of cilia.

Disease Associations

Tissue Specificity

Present in retina and testis. In brain, it is present in the cortex, striatum, globus pallidus, hypothalamus and cerebellum. Present at high level in neurons and neuropil throughout the brain (at protein level). Expressed in hippocampal neurons, where it colocalizes with HOMER1 at postsynaptic regions. {ECO:0000269PubMed:11788820, ECO:0000269PubMed:11916979, ECO:0000269PubMed:17107665}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0001843	neural tube closure
GO:0001947	heart looping
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007224	smoothened signaling pathway
GO:0016192	vesicle-mediated transport
GO:0042073	intraciliary transport
GO:0042981	regulation of apoptotic process
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060271	cilium morphogenesis
GO:0060972	left/right pattern formation

Cellular Component

GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005929	cilium
GO:0016020	membrane
GO:0030992	intraciliary transport particle B
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body
GO:0044292	dendrite terminus
GO:0072372	primary cilium