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InnateDB Protein
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IDBP-165104.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Med10
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Protein Name
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mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae)
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Synonyms
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AA959813; AI385605; C78613; D13Wsu50e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022089
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InnateDB Gene
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IDBG-165102 (Med10)
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Protein Structure
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| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Nucleus {ECO:0000305}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
1
[view]
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| Protein-Protein |
1
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
63 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0001104
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RNA polymerase II transcription cofactor activity
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GO:0003674
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molecular_function
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| Biological Process |
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0019827
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stem cell maintenance
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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| Cellular Component |
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| PDB ID |
MGI:106331
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| InterPro |
IPR019145
Mediator complex, subunit Med10
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| PFAM |
PF09748
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q9CXU0
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| PhosphoSite |
PhosphoSite-Q9CXU0
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
28077
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| UniGene |
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| RefSeq |
NP_613062
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| MGI ID |
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| MGI Symbol |
Med10
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| OMIM |
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| CCDS |
CCDS26625
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| HPRD |
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| IMGT |
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| EMBL |
AK013992
AK156498
BC048638
BC056438
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| GenPept |
AAH48638
AAH56438
BAB29103
BAE33733
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Version 5.4