Version 5.4
Mus musculus Gene: Med10
Summary
InnateDB Gene IDBG-165102.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Med10
Gene Name mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae)
Synonyms AA959813; AI385605; C78613; D13Wsu50e
Species Mus musculus
Ensembl Gene ENSMUSG00000021598
Encoded Proteins
IDBP-165104
mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133398:
MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:69809882-69816094
Strand Forward strand
Band C1
Transcripts
ENSMUST00000022089 ENSMUSP00000022089
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003674 molecular_function
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0019827 stem cell maintenance
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005654 nucleoplasm
GO:0016592 mediator complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133398
View Gene Order
ENSBTAG00000008130
Not yet available
Pathways
NETPATH
REACTOME
REACT_27166
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_200794
Mus musculus biological processes pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_233572
Gene Expression pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188576
Developmental Biology pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
REACT_227938
Generic Transcription Pathway pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_226022
Gene Expression pathway
REACT_220799
Transcriptional regulation of white adipocyte differentiation pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9CXU0
TrEMBL
UniProt Splice Variant
Entrez Gene 28077
UniGene
RefSeq NM_138596
OMIM
CCDS CCDS26625
HPRD
IMGT
MGI ID MGI:106331
MGI Symbol Med10
EMBL AK013992 AK156498 BC048638 BC056438
GenPept AAH48638 AAH56438 BAB29103 BAE33733
RNA Seq Atlas 28077

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca