InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif3k

Summary

InnateDB Protein

IDBP-165189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif3k

Protein Name

eukaryotic translation initiation factor 3, subunit K

Synonyms

1200009C21Rik; Eif3s12;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066038

InnateDB Gene

IDBG-165187 (Eif3k)

Protein Structure

UniProt Annotation

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Subcellular Localization

Nucleus {ECO:0000255HAMAP-Rule:MF_03010}. Cytoplasm {ECO:0000255HAMAP-Rule:MF_03010}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0043022	ribosome binding

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation

Cellular Component

GO:0005634	nucleus
GO:0005852	eukaryotic translation initiation factor 3 complex
GO:0016020	membrane
GO:0016282	eukaryotic 43S preinitiation complex
GO:0033290	eukaryotic 48S preinitiation complex
GO:0070062	extracellular vesicular exosome