InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfu1

Summary

InnateDB Protein

IDBP-165299.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfu1

Protein Name

NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)

Synonyms

0610006G17Rik; CGI-33; Hirip5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032060

InnateDB Gene

IDBG-165297 (Nfu1)

Protein Structure

UniProt Annotation

Function

Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0016226

iron-sulfur cluster assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1913290

InterPro

IPR001075 NIF system FeS cluster assembly, NifU, C-terminal
IPR014824 NIF system FeS cluster assembly, NifU-like scaffold, N-terminal
IPR017065 HIRA-interacting protein 5

PFAM

PF01106
PF08712

PRINTS

PIRSF

PIRSF036773

SMART

SM00932

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt