InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Blnk

Summary

InnateDB Protein

IDBP-165318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Blnk

Protein Name

B-cell linker

Synonyms

BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057844

InnateDB Gene

IDBG-165316 (Blnk)

Protein Structure

UniProt Annotation

Function

Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269PubMed:12761551, ECO:0000269PubMed:18369315, ECO:0000269PubMed:9705962}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=BCR activation results in the translocation to membrane fraction. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the spleen and weakly in thymus, no expression was seen in liver, testis, or brain. Expressed in B- cell lines representing different developmental stages from the pre-B to the plasma cell stage, but not in a T-cell or a fibroblast cell line. {ECO:0000269PubMed:9705962}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.