InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dntt

Summary

InnateDB Protein

IDBP-165372.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dntt

Protein Name

deoxynucleotidyltransferase, terminal

Synonyms

Tdt;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062078

InnateDB Gene

IDBG-165370 (Dntt)

Protein Structure

UniProt Annotation

Function

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Subcellular Localization

Isoform TDT-S: Nucleus.Isoform TDT-L: Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0003887	DNA-directed DNA polymerase activity
GO:0003912	DNA nucleotidylexotransferase activity
GO:0016779	nucleotidyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006259	DNA metabolic process
GO:0006261	DNA-dependent DNA replication
GO:0006304	DNA modification

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:98659

InterPro

IPR001357 BRCT domain
IPR001726 DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu
IPR002008 DNA polymerase, family X, beta-like
IPR002054 DNA-directed DNA polymerase X
IPR002934 Nucleotidyl transferase domain
IPR010996 DNA polymerase beta-like, N-terminal domain
IPR018944 DNA polymerase lambda, fingers domain
IPR022312 DNA polymerase family X

PFAM

PF00533
PF12738
PF01909
PF10391

PRINTS

PR00871
PR00870
PR00869

PIRSF

PIRSF000817

SMART

SM00292
SM00483

TIGRFAMs

Post-translational Modifications

Modification

Cross-References