InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dntt

Summary

InnateDB Gene

IDBG-165370.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dntt

Gene Name

deoxynucleotidyltransferase, terminal

Synonyms

Tdt

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025014

Encoded Proteins

IDBP-165372

deoxynucleotidyltransferase, terminal

IDBP-256511

deoxynucleotidyltransferase, terminal

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107447:
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3\'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:41029275-41059523

Strand

Forward strand

Band

Transcripts

ENSMUST00000051806	ENSMUSP00000062078
ENSMUST00000112200	ENSMUSP00000107819

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0003887	DNA-directed DNA polymerase activity
GO:0003912	DNA nucleotidylexotransferase activity
GO:0016779	nucleotidyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006259	DNA metabolic process
GO:0006261	DNA-dependent DNA replication
GO:0006304	DNA modification

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000107447

View Gene Order

ENSBTAG00000020427

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04640

Hematopoietic cell lineage pathway

mmu03450

Non-homologous end-joining pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04640

Hematopoietic cell lineage pathway

hsa03450

Non-homologous end-joining pathway

INOH

PID NCI

myc_represspathway

Validated targets of C-MYC transcriptional repression

dnapk_pathway

DNA-PK pathway in nonhomologous end joining

Cross-References

SwissProt

P09838

TrEMBL

Q3UZ80

UniProt Splice Variant

Entrez Gene

21673

UniGene

Mm.25620

RefSeq

NM_001043228 NM_009345

OMIM

CCDS

CCDS29807 CCDS37984

HPRD

IMGT

MGI ID

MGI:98659

MGI Symbol

Dntt

EMBL

AF316014 AF316015 AK087978 AK088709 AK134009 X04123 X68670

GenPept

AAK07884 AAK07885 BAC40071 BAC40518 BAE21978 CAA27735 CAA48634

RNA Seq Atlas

21673