InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc24a4

Summary

InnateDB Protein

IDBP-165528.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc24a4

Protein Name

solute carrier family 24 (sodium/potassium/calcium exchanger), member 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078030

InnateDB Gene

IDBG-165526 (Slc24a4)

Protein Structure

UniProt Annotation

Function

Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis. {ECO:0000269PubMed:22057188, ECO:0000269PubMed:23375655}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed in most regions of the brain, including hippocampus, neocortex, thalamus, striatum and olfactory bulb. Expressed in the olfactory sensory neurons. Expressed in late secretory-stage and maturation-stage ameloblasts, with significantly increased expression during the late stages of amelogenesis. {ECO:0000269PubMed:22677781}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005432	calcium:sodium antiporter activity
GO:0008273	calcium, potassium:sodium antiporter activity
GO:0015293	symporter activity

Biological Process

GO:0006813	potassium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007608	sensory perception of smell
GO:0035725	sodium ion transmembrane transport
GO:0050896	response to stimulus
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0097186	amelogenesis