Version 5.4
Mus musculus Protein: Itk
Summary
InnateDB Protein IDBP-165587.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itk
Protein Name IL2-inducible T-cell kinase
Synonyms Emt; Tcsk; Tsk;
Species Mus musculus
Ensembl Protein ENSMUSP00000098864
InnateDB Gene IDBG-165583 (Itk)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001865 NK T cell differentiation
GO:0032609 interferon-gamma production
GO:0032633 interleukin-4 production
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005911 cell-cell junction
Protein Structure and Domains
PDB ID MGI:96621
InterPro IPR001452 SH3 domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF00779
PF00169
PF07653
PRINTS PR00452
PR00402
PIRSF
SMART SM00326
SM00107
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q76N02
UniProt Splice Variant
Entrez Gene 16428
UniGene Mm.471366
RefSeq NP_001268896
MGI ID
MGI Symbol Itk
OMIM
CCDS CCDS70168
HPRD
IMGT
EMBL AB018562 AL662806
GenPept BAA33864

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca