Version 5.4
| Mus musculus Protein: Pmm1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-165691.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Pmm1 | ||||||||
| Protein Name | phosphomannomutase 1 | ||||||||
| Synonyms | C77612; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000023112 | ||||||||
| InnateDB Gene | IDBG-165689 (Pmm1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269PubMed:18927083}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000269PubMed:16847318}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Present in brain, where it is restricted to neuronal cell bodies. Present at lower levels in pancreas, liver, lung, gonads, uterus, adrenal glands and pituitary (at protein level). Undetectable in intestine. {ECO:0000269PubMed:16847318}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1353418 | ||||||||
| InterPro |
IPR005002
Eukaryotic phosphomannomutase IPR006379 HAD-superfamily hydrolase, subfamily IIB IPR023214 HAD-like domain |
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| PFAM |
PF03332
PF00702 PF08282 PF13419 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | O35621 | ||||||||
| PhosphoSite | PhosphoSite-O35621 | ||||||||
| TrEMBL | Q545Q8 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 29858 | ||||||||
| UniGene | Mm.18939 | ||||||||
| RefSeq | NP_038900 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Pmm1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS27678 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF007267 AK004631 AK166999 CH466550 | ||||||||
| GenPept | AAB62943 BAB23425 BAE39178 EDL04544 | ||||||||