InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc6a3

Summary

InnateDB Protein

IDBP-165716.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc6a3

Protein Name

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Synonyms

DAT; Dat1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022100

InnateDB Gene

IDBG-165714 (Slc6a3)

Protein Structure

UniProt Annotation

Function

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in the substantia nigra and ventral tegmental dopamine neurons, in fibers of the medial forebrain bundle ascending into the striatum, and within dense fiber networks and varicosities in the dorsal and ventral striatum. Lower expression in the cortex. Absent from the corpus callosum. {ECO:0000269PubMed:19357284}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005102	receptor binding
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005329	dopamine transmembrane transporter activity
GO:0005330	dopamine:sodium symporter activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008504	monoamine transmembrane transporter activity
GO:0032403	protein complex binding
GO:0035240	dopamine binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0007568	aging
GO:0007595	lactation
GO:0007608	sensory perception of smell
GO:0007626	locomotory behavior
GO:0010039	response to iron ion
GO:0014070	response to organic cyclic compound
GO:0015844	monoamine transport
GO:0015872	dopamine transport
GO:0021984	adenohypophysis development
GO:0035094	response to nicotine
GO:0040018	positive regulation of multicellular organism growth
GO:0042053	regulation of dopamine metabolic process
GO:0042220	response to cocaine
GO:0042416	dopamine biosynthetic process
GO:0042420	dopamine catabolic process
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0051591	response to cAMP
GO:0055085	transmembrane transport
GO:0060134	prepulse inhibition

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043005	neuron projection
GO:0043025	neuronal cell body