InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Med7

Summary

InnateDB Protein

IDBP-165752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med7

Protein Name

mediator complex subunit 7

Synonyms

1110063B05Rik; Crsp33; Crsp9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020665

InnateDB Gene

IDBG-165750 (Med7)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0019827	stem cell maintenance