Version 5.4
Mus musculus Gene: Med7
Summary
InnateDB Gene IDBG-165750.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Med7
Gene Name mediator complex subunit 7
Synonyms 1110063B05Rik; Crsp33; Crsp9
Species Mus musculus
Ensembl Gene ENSMUSG00000020397
Encoded Proteins
IDBP-165752
mediator complex subunit 7
IDBP-262830
mediator complex subunit 7
IDBP-262832
mediator complex subunit 7
IDBP-533413
mediator complex subunit 7
IDBP-542171
mediator complex subunit 7
IDBP-533713
mediator complex subunit 7
IDBP-533061
mediator complex subunit 7
IDBP-621453
mediator complex subunit 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155868:
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:46436925-46442721
Strand Forward strand
Band B1.1
Transcripts
ENSMUST00000020665 ENSMUSP00000020665
ENSMUST00000109232 ENSMUSP00000104855
ENSMUST00000109231 ENSMUSP00000104854
ENSMUST00000152119 ENSMUSP00000122182
ENSMUST00000140027 ENSMUSP00000120077
ENSMUST00000128940 ENSMUSP00000116997
ENSMUST00000156073
ENSMUST00000133635 ENSMUSP00000120617
ENSMUST00000170928 ENSMUSP00000131852
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0005515 protein binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0019827 stem cell maintenance
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005739 mitochondrion
GO:0016592 mediator complex
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000155868
View Gene Order
ENSBTAG00000000495
Not yet available
Pathways
NETPATH
REACTOME
REACT_27166
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_200794
Mus musculus biological processes pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_233572
Gene Expression pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188576
Developmental Biology pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.24159
RefSeq NM_001104530 NM_001104556 NM_001104557 NM_025426 XM_006533932 XM_006533934
OMIM
CCDS CCDS36134
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca