InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmp10

Summary

InnateDB Protein

IDBP-165764.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmp10

Protein Name

bone morphogenetic protein 10

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032125

InnateDB Gene

IDBG-165762 (Bmp10)

Protein Structure

UniProt Annotation

Function

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

In the embryo, expressed exclusively in the ventricular trabecular myocardium of the developing heart from E9.0-E13.5. By E16.5-E18.5, only detectable in atria. Highly expressed in the adult heart where it is found in the right atrium but not in the left atrium. Lower levels in adult liver and lung. {ECO:0000269PubMed:10072785, ECO:0000269PubMed:15073151, ECO:0000269PubMed:15109497}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0033612	receptor serine/threonine kinase binding

Biological Process

GO:0007155	cell adhesion
GO:0007507	heart development
GO:0007512	adult heart development
GO:0010596	negative regulation of endothelial cell migration
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0010628	positive regulation of gene expression
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030509	BMP signaling pathway
GO:0032924	activin receptor signaling pathway
GO:0040007	growth
GO:0045214	sarcomere organization
GO:0045893	positive regulation of transcription, DNA-templated
GO:0055009	atrial cardiac muscle tissue morphogenesis
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0055015	ventricular cardiac muscle cell development
GO:0055117	regulation of cardiac muscle contraction
GO:0060038	cardiac muscle cell proliferation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060298	positive regulation of sarcomere organization
GO:0060347	heart trabecula formation
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0030018	Z disc

Protein Structure and Domains

PDB ID

MGI:1338820

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR00669

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt