InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bmp10

Summary

InnateDB Gene

IDBG-165762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmp10

Gene Name

bone morphogenetic protein 10

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030046

Encoded Proteins

IDBP-165764

bone morphogenetic protein 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163217:
The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:87429002-87434512

Strand

Forward strand

Band

Transcripts

ENSMUST00000032125

ENSMUSP00000032125

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0033612	receptor serine/threonine kinase binding

Biological Process

GO:0007155	cell adhesion
GO:0007507	heart development
GO:0007512	adult heart development
GO:0010596	negative regulation of endothelial cell migration
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0010628	positive regulation of gene expression
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030509	BMP signaling pathway
GO:0032924	activin receptor signaling pathway
GO:0040007	growth
GO:0045214	sarcomere organization
GO:0045893	positive regulation of transcription, DNA-templated
GO:0055009	atrial cardiac muscle tissue morphogenesis
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0055015	ventricular cardiac muscle cell development
GO:0055117	regulation of cardiac muscle contraction
GO:0060038	cardiac muscle cell proliferation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060298	positive regulation of sarcomere organization
GO:0060347	heart trabecula formation
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis