InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lcor

Summary

InnateDB Protein

IDBP-165931.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lcor

Protein Name

ligand dependent nuclear receptor corepressor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067603

InnateDB Gene

IDBG-165927 (Lcor)

Protein Structure

UniProt Annotation

Function

Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (By similarity). May act as transcription activator that binds DNA elements with the sequence 5'- CCCTATCGATCGATCTCTACCT-3'. {ECO:0000250, ECO:0000269PubMed:12560079}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00320}.

Disease Associations

Tissue Specificity

Detected in heart and kidney. {ECO:0000269PubMed:12560079}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter