Version 5.4
Mus musculus Gene: Lcor
Summary
InnateDB Gene IDBG-165927.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lcor
Gene Name ligand dependent nuclear receptor corepressor
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025019
Encoded Proteins
IDBP-165931
ligand dependent nuclear receptor corepressor
IDBP-621494
ligand dependent nuclear receptor corepressor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196233:
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:41482645-41562246
Strand Forward strand
Band C3
Transcripts
ENSMUST00000067795 ENSMUSP00000067603
ENSMUST00000163929 ENSMUSP00000126441
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196233
View Gene Order
ENSBTAG00000004029
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt Q6ZPI3
TrEMBL A4FTY7
UniProt Splice Variant
Entrez Gene 212391
UniGene Mm.413335 Mm.422910
RefSeq NM_172154 XM_006526848 XM_006526849 XM_006526850
OMIM
CCDS CCDS29810
HPRD
IMGT
MGI ID MGI:2443930
MGI Symbol Lcor
EMBL AB076079 AK041090 AK041621 AK129442 AK155007 BC050068 BC090652 BC099938 CH466534
GenPept AAH50068 AAH90652 AAH99938 BAC20955 BAC30816 BAC31007 BAC98252 BAE32988 EDL41857
RNA Seq Atlas 212391

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca