Version 5.4
Mus musculus Protein: Spred3
Summary
InnateDB Protein IDBP-166164.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spred3
Protein Name sprouty-related, EVH1 domain containing 3
Synonyms AW047143; D130060H24Rik; Spred-3;
Species Mus musculus
Ensembl Protein ENSMUSP00000046216
InnateDB Gene IDBG-166162 (Spred3)
Protein Structure
UniProt Annotation
Function Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase.
Subcellular Localization Membrane {ECO:0000269PubMed:12646235}; Peripheral membrane protein {ECO:0000269PubMed:12646235}.
Disease Associations
Tissue Specificity Brain specific. {ECO:0000269PubMed:12646235}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0007275 multicellular organismal development
GO:0009966 regulation of signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2142186
InterPro IPR000697 WH1/EVH1
IPR007875 Sprouty
PFAM PF00568
PF05210
PRINTS
PIRSF
SMART SM00461
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P6N5
PhosphoSite PhosphoSite-Q6P6N5
TrEMBL
UniProt Splice Variant
Entrez Gene 101809
UniGene Mm.484186
RefSeq NP_891557
MGI ID
MGI Symbol Spred3
OMIM
CCDS CCDS21065
HPRD
IMGT
EMBL AB115762 BC062119
GenPept AAH62119 BAC80222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca