InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wdr19

Summary

InnateDB Protein

IDBP-166170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wdr19

Protein Name

WD repeat domain 19

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038098

InnateDB Gene

IDBG-166168 (Wdr19)

Protein Structure

UniProt Annotation

Function

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (By similarity). Involved in cilia function and/or assembly. {ECO:0000250}.

Subcellular Localization

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to photoreceptor connecting cilia, to the base of motile cilia in brain ependymal cells and to the base of and along primary cilia in cultured kidney inner mnedullary collecting duct (IMCD) cells.

Disease Associations

Tissue Specificity

Tissue-specific expression of isoforms. Expressed in the prostate, testis, epididymis, submaxillary and salivary glands. Expressed in ependymal cells lining brain ventricles (at protein level). {ECO:0000269PubMed:12906858, ECO:0000269PubMed:16957054}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0007224	smoothened signaling pathway
GO:0030326	embryonic limb morphogenesis
GO:0031076	embryonic camera-type eye development
GO:0035721	intraciliary retrograde transport
GO:0042384	cilium assembly
GO:0042471	ear morphogenesis
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0050877	neurological system process
GO:0055123	digestive system development
GO:0060271	cilium morphogenesis
GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061055	myotome development

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005929	cilium
GO:0030991	intraciliary transport particle A
GO:0031513	nonmotile primary cilium
GO:0031514	motile cilium
GO:0032391	photoreceptor connecting cilium