InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC1A3

Summary

InnateDB Protein

IDBP-16620.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC1A3

Protein Name

solute carrier family 1 (glial high affinity glutamate transporter), member 3

Synonyms

EA6; EAAT1; GLAST; GLAST1;

Species

Homo sapiens

Ensembl Protein

ENSP00000265113

InnateDB Gene

IDBG-16618 (SLC1A3)

Protein Structure

UniProt Annotation

Function

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Episodic ataxia 6 (EA6) [MIM:612656]: A disorder characterized by episodic ataxia, seizures, migraine and alternating hemiplegia. {ECO:0000269PubMed:16116111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0005314	high-affinity glutamate transmembrane transporter activity
GO:0005515	protein binding
GO:0016595	glutamate binding
GO:0016597	amino acid binding
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0001504	neurotransmitter uptake
GO:0006536	glutamate metabolic process
GO:0006537	glutamate biosynthetic process
GO:0006811	ion transport
GO:0006835	dicarboxylic acid transport
GO:0007268	synaptic transmission
GO:0007605	sensory perception of sound
GO:0009416	response to light stimulus
GO:0009449	gamma-aminobutyric acid biosynthetic process
GO:0009611	response to wounding
GO:0015813	L-glutamate transport
GO:0021545	cranial nerve development
GO:0031223	auditory behavior
GO:0042493	response to drug
GO:0046677	response to antibiotic
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0050806	positive regulation of synaptic transmission
GO:0050885	neuromuscular process controlling balance
GO:0051938	L-glutamate import
GO:0055085	transmembrane transport
GO:0070779	D-aspartate import

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043205	fibril